Recombinant Human CLEC10A/CD301 Protein (Fc Tag)

Size: 50μg

Catalogue Number: PKSH031411-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: CLEC10A, CD301

Target Synonym: C-Type Lectin Domain Family 10 Member A, C-Type Lectin Superfamily Member 14, Macrophage Lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML

UNIProt ID: Q8IUN9

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: N-hFc

Accession: Q8IUN9-2

Background: CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs, CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD301a and CD301b) in mice. MGL1/CD301a induces both the production and secretion of interleukin (IL)-10. MGL1/CD301a plays a protective role against colitis by effectively inducing IL-10 production by colonic lamina propria macrophages in response to invading commensal bacteria.

Sequence: Gln61-His292

Purity: > 85 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 54.6 kDa

Observed MW: 58 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only