m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 874208-94-3

Molecular Weight: 377.39

Formula: C16H27NO9

Chemical Name: 2,5-dioxopyrrolidin-1-yl 2,5,8,11,14-pentaoxaheptadecan-17-oate

Smiles: COCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

InChiKey: FMMFVGSOBIANGY-UHFFFAOYSA-N

InChi: InChI=1S/C16H27NO9/c1-21-6-7-23-10-11-25-13-12-24-9-8-22-5-4-16(20)26-17-14(18)2-3-15(17)19/h2-13H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

1. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

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