Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity.

Product information

CAS Number: 55335-06-3

Molecular Weight: 256.47

Formula: C7H4Cl3NO3

Chemical Name: 2-[(3,5,6-trichloropyridin-2-yl)oxy]acetic acid

Smiles: OC(=O)COC1=NC(Cl)=C(Cl)C=C1Cl

InChiKey: REEQLXCGVXDJSQ-UHFFFAOYSA-N

InChi: InChI=1S/C7H4Cl3NO3/c8-3-1-4(9)7(11-6(3)10)14-2-5(12)13/h1H,2H2,(H,12,13)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Triclopyr (3 mM; 48 hours) treatment exhibits cytotoxicity against N2a cells.

In Vivo:

Pharmacokinetic Analysis Triclopyr exhibits moderate half-lives (dog 25 h and monkey 6.3 h) due to plasma clearance (18 mL/h/kg, 26 mL/h/kg respectively) following oral gavage (3 male beagle dogs ;0.5 mg/kg, 5 mg/kg and 20 mg/kg) and intravenous administration (1 male rhesus monkey; 30 mg/kg) .

References:

1. Tejaswini P Reddy, et al. Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int J Environ Res Public Health. 2011 Jan;8(1):203-21.
2. C Timchalk, et al. Pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) in the beagle dog and rhesus monkey: perspective on the reduced capacity of dogs to excrete this organic acid relative to the rat, monkey, and human. Toxicol Appl Pharmacol. 1997 Jun;144(2):268-78.

Products are for research use only. Not for human use.